منابع مشابه
Preparation of sterically congested 1,3,4-oxadiazole derivatives from N-isocyaniminotriphenylphosphorane, aromatic acids, cyclopentanone and primary amines
Reactions of N-isocyaniminotriphenylphosphorane with cyclopentanone have been studied in the presence of aromatic carboxylic acids and primary amines, proceeds smoothly at room temperature under neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives by an intramolecular Aza-Wittig cyclization in CH2Cl2 in excellent yields. The structures of the products were deduced from...
متن کاملNitrosamines and Aromatic Amines
A new method for the simultaneous determination of hemoglobin adducts from aromatic amines and tobacco-specific nitrosamines (TSNA) is described. After mild base-catalysed hydrolysis releasing aromatic amines and the TSNA adduct 4-hydroxy-1-(3-pyridyl)-1butanone (HPB), the extraction, cleanup, and concentration are performed by a one-step procedure using C 1 8 cartridges. Determination in the p...
متن کاملThe Biochemistry of Aromatic Amines
1. 2-Naphthylhydroxylamine and 2-nitrosonaphthalene were present in urine of dogs but not of guinea pigs, hamsters, rabbits or rats dosed with 2-naphthylamine. N-Acetyl-2-naphthylhydroxylamine and its O-sulphonic acid and O-glucosiduronic acid were not detected in the urine of any of these species. 2. Bile from rats dosed with 2-naphthylamine contained (2-naphthylamine N-glucosid)uronic acid an...
متن کاملpreparation of sterically congested 1,3,4-oxadiazole derivatives from n-isocyaniminotriphenylphosphorane, aromatic acids, cyclopentanone and primary amines
reactions of n-isocyaniminotriphenylphosphorane with cyclopentanone have been studied in the presence of aromatic carboxylic acids and primary amines, proceeds smoothly at room temperature under neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives by an intramolecular aza-wittig cyclization in ch2cl2 in excellent yields. the structures of the products were deduced from...
متن کاملTransformation of cultured mouse mammary glands by aromatic amines and amides and their derivatives.
Mouse mammary glands in whole organ culture, previously demonstrated by others to undergo lobuloalveolar develop ment, functional differentiation, and glandular involution, are transformable by carcinogenic aryl amines and amides and their derivatives. The transformation, which involves an escape from the hormonal controls of these processes, results in the formation of nodule-like alveolar les...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1915
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)88216-3